We are seeking highly motivated postdoctoral fellow candidates to join the laboratory of Brett McCray, MD, PhD, at the University of Michigan to lead studies elucidating mechanisms of hereditary neuromuscular disease. Our primary focus is on diseases caused by mutations in the ion channel TRPV4, which result in Charcot-Marie-Tooth disease type 2C and related forms of spinal muscular atrophy. In collaboration with Dr. McCray and other members of the laboratory, the fellow will contribute to the design, management, coordination, and implementation of in vitro and in vivo studies focused on defining mechanisms of disease pathogenesis. Specific potential pathogenic mechanisms to explore include the role of TRPV4 in regulating actin cytoskeletal dynamics and the integrity of blood-brain barriers. Candidates should have a doctoral degree and strong research background with expertise in molecular and cellular biology. This is an interdisciplinary project with opportunities to learn new skills in biochemistry and molecular and cellular biology, including fluorescence microscopy, live-cell imaging, ratiometric calcium imaging, transcriptomics, proteomics, mammalian cell culture, induced pluripotent stem cell culture/differentiation, utilization of microfluidic devices, immunohistochemistry, and mouse models of disease. Opportunities to become involved in clinical research projects are also available.

• Design, perform, analyze, and interpret experiments independently. Experimental approaches will include culture of immortalized and stem cell-derived cells; analysis of protein-protein interactions; live imaging of calcium dynamics, cytoskeletal changes, and molecular biosensors; immunohistochemistry; mouse behavior and histology; and additional biochemistry and cellular biology approaches. 
• Organize and present data at scientific seminars and conferences
• Write manuscripts for publication
• Support mentorship of undergraduate students and technical personnel

• Possess a Ph.D. in Neuroscience, Biochemistry, Cell Biology, or medical-related field with significant experience in molecular and cellular biology 
• Have strong oral and written communication skills
• Have a positive, collaborative, and flexible attitude suitable for working in an academic laboratory environment

• Experience with fluorescence microscopy

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

The University of Michigan is an equal employment opportunity employer.