The Castro/Lowenstein Laboratory within the Department of Neurosurgery at the University of Michigan Medical School, is pleased to accept Dr. Xiangdong Yin, who is a PKU-Scholar as a trainee to join an exciting and productive research team focused on elucidating the molecular and mechanistic aspects which underlie brain tumor growth, invasion, and the response to novel immune mediated therapeutics. The applicant will be engaged in a project that will study the molecular and cellular mechanisms involved in tumor progression; the role of the extracellular matrix on tumor growth and invasion; the mechanisms which underpin immune mediated gene therapies, leading to tumor regression and anti-glioma immunological memory to prevent recurrences. The project will also utilize state-of-the-art ?omics? technologies such as Single Cell RNASeq, ChIP-Seq, ATAC-Seq, as well as advanced Bioinformatics. The candidate will also learn immunological functional assays and 3D-multiplex immunohistochemistry to uncover cell-cell interactions and immune neighborhoods in the tumor microenvironment. The project has a strong translational component focusing on the development and implementation of novel therapeutic approaches in human clinical trials for brain cancer; these include gene therapy strategies, small molecules, and nanotechnologies. The candidate will have the opportunity to learn the mechanisms of action of novel gene therapy and combination therapies and explore ways that our team will implement to translate the research into novel Phase I clinical trials for GBM