Provide your CV with brief cover letter describing your research experiences and ongoing research interests (including specific interest in this lab) as well as contact information for three references.

Type 2 Diabetes (T2D) dysfunction and genetic associations involve mitochondrial biology pathways. The Parker lab seeks applicants to work on a project studying the effect of single-cell resolution and context-specific regulatory variants and transcriptional control elements at T2D GWAS signals. The focus will be on mitochondrial function in T2D disease-relevant cells/tissues. The individual will help organize and lead the research project involving molecular biology, statistical genetics, functional genomics, and metabolic assays using the Agilent Seahorse technology, and should serve as an expert in one of these specialized areas. The individual will also contribute to other research projects within the laboratory. The candidate should be able to work both independently and in a team environment and will be responsible for processing human tissue samples and cultured cell lines for these analyses. The candidate will be expected to perform basic laboratory maintenance/upkeep as well as maintaining compliance with University of Michigan safety and lab regulations. They will assist in development of research goals with responsibility for a substantial portion of project work and be expected to provide input into the development of procedures and research design.

Projects in the Parker lab are focused on human molecular genetic and metabolic techniques including cell culture, PCR, qPCR, gel electrophoresis, cloning, DNA and RNA isolation, library preparation for high-throughput sequencing, and Seahorse assays. These approaches are applied to human tissues and cells to profile molecular signatures at bulk and single cell multi-omics (RNA-seq, ATAC-seq) levels as well as to identify effects on mitochondrial and metabolic function. The candidate should be open to learning new cutting-edge methods and techniques as research opportunities develop and directions change.

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

The laboratory of Dr. Steve Parker is in the Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, Human Genetics, and Biostatistics at the University of Michigan. Our major goal is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome (from GWAS), with a focus on metabolic traits. We accomplish this through an interdisciplinary combination of molecular/cellular and computational approaches. We generate multiple high-throughput functional genomics data sets on the genome, epigenome, and transcriptome across species and in disease-relevant tissues/cells at single-cell multi-omic resolution and use computational approaches to integrate and analyze this data. The lab culture is one of openness, scientific rigor, friendliness, and general good humor. To help enable this lab culture, we invest in supporting the people on our team. For example, we have quarterly wellness meetings and an annual wellness retreat. For more general information, please see the Parker lab website: http://theparkerlab.org/

B.S. in Cell Biology, Molecular Biology, or related field and 1-3 years of experience in a molecular biology lab setting with excellent cell culture, cell metabolism, and PCR/qPCR skills. The candidate should have strong written and oral communication skills and be able to critically evaluate and present scientific literature. The candidate will be asked to work collaboratively with senior research faculty and personnel, maintain laboratory records, and work under deadlines with general guidance. They will be expected to contribute to manuscripts, grants and presentations. English language proficiency is required.

M.S. degree or higher and more experience is preferred. Experience with the Agilent Seahorse technology is highly desired.

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

The University of Michigan is an equal employment opportunity employer.